Ensuring American Pharmaceutical Supply Chain Resilience by Filling the Strategic Active Pharmaceutical Ingredients Reserve

The order directs federal agencies to enhance the resilience of the American pharmaceutical supply chain by filling the Strategic Active Pharmaceutical Ingredients Reserve (SAPIR). The Assistant Secretary for Preparedness and Response (ASPR) within the Department of Health and Human Services is instructed to develop a list of approximately 26 critical drugs and secure a 6-month supply of Active Pharmaceutical Ingredients (APIs) for these drugs. The ASPR is also tasked with preparing the existing SAPIR repository to receive and maintain APIs. Furthermore, the ASPR is directed to provide a plan for obtaining, storing, and maintaining a 6-month supply of APIs for essential medicines, along with a proposal for opening a second SAPIR repository in the United States within a year.