The order directs Federal agencies to identify unlawful and potentially unlawful regulations within 60 days and initiate plans to repeal them. The review and repeal effort should prioritize evaluating the lawfulness of each regulation under specific United States Supreme Court decisions. Following the review period, agencies are instructed to immediately repeal any regulation that clearly exceeds the agency’s statutory authority or is otherwise unlawful, and within 30 days, submit a summary of each regulation not targeted for repeal to the Office of Information and Regulatory Affairs, explaining the decision.

The order directs Federal agencies to review all regulations under their authority and identify those that may be anti-competitive. The heads of these agencies are to collaborate with the Chairman of the Federal Trade Commission and the Attorney General, and within 70 days, provide a list of such regulations and recommendations for their rescission or modification. The Chairman, in consultation with the Attorney General and the Director of the Office of Management and Budget, will then consolidate these lists and decide on the proposed changes.

The FDA is planning to hire contractors to cover tasks formerly carried out by laid off staff. In early April the agency let go about 60 employees who coordinated travel and logistics for inspectors and others. The agency is now seeking contractors to fill those roles.

The president announced that Fox News host Jeanine Pirro had been named interim U.S. Attorney for D.C. and that she would be the nominee for the position. Ed Martin had been in that role until his nomination ran into opposition from Republicans in the Senate.

The Trump II administration fired the Librarian of Congress over email, with no explanation. Carla Hayden had served in the role since 2016. In addition to overseeing the LOC, Hayden led the U.S. Copyright Office and the Congressional Research Service.

The president fired three Democratic members of the five-member Consumer Product Safety Commission. The CPSC is an independent agency and its members can only be removed because of malfeasance or neglect of duty. The sacked commissioners intend to sue.

The Supreme Court said President Trump likely has the authority to fire independent agency board members. The ruling stayed a lower court order that had reinstated a National Labor Relations Board member and one from the Merit Systems Protection Board. In its order, the Supreme Court carved out an exception for the Chairman of the Federal Reserve, saying the president did not have the authority to fire the head of that particular independent agency.

The order directs federal agencies to halt the filling of vacant civilian positions and the creation of new ones through October 15, 2025, except as otherwise specified or required by law. This directive applies to all executive departments and agencies, with exceptions for military personnel, positions related to immigration enforcement, national security, public safety, and the Executive Office of the President. The hiring process should align with the Merit Hiring Plan issued by the Office of Personnel Management (OPM) on May 29, 2025. The OPM Director may grant exemptions where necessary, and agencies are prohibited from contracting outside the federal government to circumvent this policy.

The order directs federal agencies to close and excuse their employees from duty on December 24, 2025, and December 26, 2025. However, the heads of these departments and agencies may require certain offices or employees to remain operational for reasons of national security, defense, or other public need. The Director of the Office of Personnel Management is instructed to implement this order.

The order directs federal agencies to withdraw the United States from certain international organizations, conventions, and treaties deemed contrary to the country's interests. The Secretary of State, in consultation with the United States Representative to the United Nations, was previously tasked to review all such international affiliations. Based on the review's findings, the order now dictates immediate steps to cease participation in or funding for a listed set of organizations, including various non-United Nations and United Nations entities, as permitted by law.