The proclamation designates May 1, 2025, as Loyalty Day and Law Day, U.S.A. It calls on all Americans to reflect on the importance of the rule of law and display the American flag in support of this national observance. Government officials are urged to display the flag on all government buildings and grounds on this day.

The order directs federal agencies to establish the Religious Liberty Commission. This Commission, composed of up to 14 appointed members and ex officio members including the Attorney General, the Secretary of Housing and Urban Development, and the Assistant to the President for Domestic Policy, is tasked with producing a comprehensive report on the foundations of religious liberty in America, its impact on society, current threats to it, strategies to preserve and enhance protections for future generations, and programs to increase awareness of and celebrate America’s peaceful religious pluralism. The Commission will also examine specific areas such as First Amendment rights, attacks on houses of worship, and parents’ authority over their children's education.

The order directs federal agencies to enforce English proficiency requirements for commercial vehicle operators. The Secretary of Transportation, through the Federal Motor Carrier Safety Administration (FMCSA), is instructed to rescind a 2016 guidance document and issue new guidance to ensure compliance with English language proficiency requirements. The FMCSA is also directed to review non-domiciled commercial driver’s licenses for irregularities and improve verification of driving credentials. Additionally, the Secretary of Transportation is tasked with identifying actions to improve the working conditions of truck drivers.

The order directs federal agencies to identify and take action against jurisdictions that obstruct the enforcement of federal immigration laws, often referred to as "sanctuary" jurisdictions. The Attorney General and the Secretary of Homeland Security are instructed to publish a list of these jurisdictions, notify them of their noncompliance, and pursue legal remedies to bring them into compliance. Additionally, the order mandates the suspension or termination of federal funds to these jurisdictions, as well as the development of mechanisms to verify eligibility for federal public benefits in these areas. It also requires action against local laws favoring aliens over American citizens.

The order directs federal agencies to provide resources and support to state and local law enforcement. The Attorney General is instructed to establish a mechanism to provide legal resources to law enforcement officers who face expenses and liabilities for actions taken in their official duties. The Attorney General and other relevant agency heads are also directed to maximize the use of federal resources to provide best practices, expand training, increase pay and benefits, and strengthen legal protections for law enforcement officers. Additionally, the Attorney General and the Secretary of Defense are instructed to increase the provision of military and national security assets to assist local law enforcement. The Attorney General is also tasked with pursuing legal remedies against state and local officials who obstruct law enforcement or engage in discrimination under the guise of diversity initiatives.

A Biden Administration regulation to tighten inspections at poultry plants is withdrawn by the USDA. The rule would have required chicken producers to limit levels of salmonella bacteria in their products.

The order directs Federal agencies to review all regulations under their authority and identify those that may be anti-competitive. The heads of these agencies are to collaborate with the Chairman of the Federal Trade Commission and the Attorney General, and within 70 days, provide a list of such regulations and recommendations for their rescission or modification. The Chairman, in consultation with the Attorney General and the Director of the Office of Management and Budget, will then consolidate these lists and decide on the proposed changes.

The order directs Federal agencies to review all regulations under their rulemaking authority, in consultation with the Chairman of the Federal Trade Commission and the Attorney General. This review is aimed at identifying regulations that create monopolies, unnecessary barriers to new market entrants, limit competition, unduly limit competition through licensure or accreditation requirements, burden procurement processes, or impose anti-competitive restraints on the free market. Within 70 days, agency heads must provide a list of such regulations and recommendations for rescission or modification due to their anti-competitive effects.

The order directs Federal agencies to incorporate a sunset provision into their regulations governing energy production, compelling these agencies to periodically reexamine their regulations to ensure public benefit. The agencies affected include the Environmental Protection Agency (EPA), the Department of Energy (DoE), the Federal Energy Regulatory Commission (FERC), the Nuclear Regulatory Commission (NRC), and several subcomponents of the Department of the Interior and the United States Army. The order applies to all regulations issued under specific statutes, as detailed in the order, by each of these agencies.

The order directs Federal agencies to recognize April 2025 as National Donate Life Month. It encourages all eligible individuals, regardless of age or medical history, to consider becoming organ donors and share this decision with family and loved ones. The order also mentions the option to register through state registries, the Department of Motor Vehicles, or www.organdonor.gov.

The order directs Federal agencies to focus on groundbreaking medical advancements and innovative treatments to combat and prevent cancer. It establishes the Make America Healthy Again Commission to address the root causes of America’s chronic disease crisis. The order also emphasizes the need for transparency and the elimination of conflicts of interest in federally-funded health research, and promotes the use of emerging technologies such as artificial intelligence for research in genomics and immunotherapy.

The order directs Federal agencies to discontinue the duty-free de minimis treatment for products from the People's Republic of China (PRC), including Hong Kong, that are implicated in the synthetic opioid crisis. These products will now be subject to duties as described in the order, effective from May 2, 2025. The Department of Homeland Security, through U.S. Customs and Border Protection (CBP), is instructed to implement the necessary actions to enforce this order, including potential temporary suspension or amendment of regulations or notices. The United States International Trade Commission is also directed to adjust the Harmonized Tariff Schedule of the United States as needed to reflect these changes.

The order directs Federal agencies to regulate imports with a reciprocal tariff to rectify trade practices that contribute to large and persistent annual U.S. goods trade deficits. It calls for an investigation into the causes of these deficits, including the economic and national security implications, as well as a review of any unfair trade practices by other countries. The order also emphasizes the need to address non-reciprocal trading practices of U.S. trading partners and the impact of their domestic economic policies on U.S. trade.

The order directs Federal agencies to prioritize gold-standard research and increase transparency to gain new insights to aid those with Autism Spectrum Disorder (ASD). It also emphasizes the importance of early detection and intervention to improve long-term outcomes for individuals with ASD. The order calls on all Americans to learn more about the signs of autism to improve early diagnosis, understand the challenges faced by individuals with autism, and find ways to support those with autism and their families.

The order directs Federal agencies to address unfair practices in the live entertainment industry. Specifically, the Attorney General and the Federal Trade Commission (FTC) are ordered to enforce competition laws in the concert and entertainment industry, rigorously enforce the Better Online Tickets Sales Act, ensure price transparency in the ticket-purchase process, and prevent unfair, deceptive, and anti-competitive conduct in the secondary ticketing market. Additionally, the Secretary of the Treasury and Attorney General are directed to ensure that ticket scalpers comply with the Internal Revenue Code and other applicable laws.

The order directs Federal agencies, specifically the Department of Commerce, in coordination with the Secretary of the Treasury and the Assistant to the President for Economic Policy, to establish an office named the United States Investment Accelerator within 30 days. The Investment Accelerator is tasked with facilitating and accelerating investments exceeding $1 billion in the United States, by assisting investors in navigating regulatory processes, reducing regulatory burdens, increasing access to national resources, facilitating research collaborations with national labs, and working with State governments to reduce regulatory barriers. The Investment Accelerator will be headed by an Executive Director and will also be responsible for the CHIPS Program Office within the Department of Commerce.

The order directs Federal agencies to work closely with local officials to make the District of Columbia safe, beautiful, and prosperous. A Task Force, named the D.C. Safe and Beautiful Task Force, is established, including representatives from the Department of the Interior, Department of Transportation, Department of Homeland Security, Federal Bureau of Investigation, United States Marshals Service, Bureau of Alcohol, Tobacco, Firearms and Explosives, and the United States Attorney’s Offices for the District of Columbia, District of Maryland, and Eastern District of Virginia. The Task Force will focus on crime prevention, preservation of monuments, promoting beautification, and sharing resources and information with local officials.

The Federal Deposit Insurance Corporation announced that banks can engage in crypto-related activities without prior approval, undoing a Biden-era mandate. Meanwhile, the Commodity Futures Trading Commission said that digital asset derivatives will be treated the same as other derivatives, eliminating previous uncertainties in the crypto derivatives market.

Vice President JD Vance visited the U.S. Pituffik Space Base in Greenland alongside his wife and national security adviser Mike Waltz, where he criticized Denmark for insufficient regional security. Vance cited growing Russian and Chinese influence in the Arctic.

The order directs Federal agencies to suspend any active security clearances held by individuals at WilmerHale, pending a review of whether such clearances are consistent with national interest. The Office of Management and Budget is instructed to identify all government goods and services provided for WilmerHale's benefit, and agency heads are to cease provision of such materials or services where legally permissible. The order also requires government contracting agencies to demand disclosure of any business contractors do with WilmerHale, and agency heads are to review all contracts with WilmerHale or entities that disclose doing business with them, with steps to be taken to terminate any such contracts where legally allowed.

The order directs Federal agencies to adjust imports of automobiles and automobile parts into the United States, based on a report from the Secretary of Commerce regarding the effects of these imports on national security. The United States Trade Representative, in consultation with other executive branch officials, is directed to negotiate agreements to address the threat to national security from imported automobiles and certain parts from the European Union, Japan, and any other deemed appropriate countries. Additionally, the Secretary of Commerce is instructed to monitor these imports and report any circumstances that might indicate the need for further action.

The order directs Federal agencies to suspend any active security clearances held by individuals at Jenner & Block LLP (Jenner), pending a review of whether such clearances align with national interest. The Office of Management and Budget is directed to identify all Government goods, property, material, and services provided for Jenner's benefit, with relevant agency heads ordered to cease such provision where legally permitted. Agencies are also instructed to require Government contractors to disclose any business they do with Jenner and to review all contracts with Jenner or entities doing business with Jenner. If permitted by law, agencies are to take steps to terminate any contracts for which Jenner has been hired to perform any service.

The order directs Federal agencies to enforce laws that protect the integrity of American elections. This includes ensuring that votes are cast and received by the legally established election date, prohibiting non-citizens from registering to vote or voting in Federal elections, and maintaining accurate and current Statewide lists of legally registered voters. The order also calls for the enforcement of laws that prevent foreign nationals from participating in Federal, State, or local elections by making contributions or expenditures.

The order directs Federal agencies to improve financial integrity and operational efficiency. Specifically, the Department of the Treasury is tasked with implementing stronger controls to track transactions through the United States General Fund, requiring additional financial information from other agencies. The order also mandates agencies to provide the Treasury with more detailed data to track transactions, centralizes disbursing functions to the Treasury where possible, and standardizes core Federal financial systems to increase transparency, accountability, and efficiency.

Directs federal agencies to suspend security clearances of law firm Jenner & Block employees, cease providing government resources to the firm, and review federal contracts involving Jenner & Block or entities associated with it.

The axed “SPCP” programs targeted historically underserved regions and communities and offered down payment assistance, relaxed credit requirements, closing cost credits, etc, to make buying a home easier.

Directs agencies to phase out paper checks for federal payments by September 30, 2025, citing cost savings and fraud reduction.

A 2022 law requires the disclosure of executive department apportionment decisions. The shutdown database is where those disclosures were posted for public review.

Revokes Executive Order 14237 after Paul, Weiss, Rifkind, Wharton & Garrison LLP acknowledged prior misconduct and committed to reforms, including political neutrality in client selection and merit-based hiring. The firm also pledged $40 million in pro bono services during the President’s term to support causes such as assisting veterans and combating anti-Semitism.

Immediate Measures to Increase American Mineral Production. Invokes the Defense Production Act to boost domestic mineral production.